Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD

Nonmicrobial inflammation contributes to CKD progression and fibrosis. Absent in melanoma 2 (AIM2) is an inflammasome-forming receptor for double-stranded DNA. AIM2 is expressed in the kidney and activated mainly by macrophages. We investigated the potential pathogenic role of the AIM2 inflammasome...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Am Soc Nephrol
Egile Nagusiak: Komada, Takanori, Chung, Hyunjae, Lau, Arthur, Platnich, Jaye M., Beck, Paul L., Benediktsson, Hallgrimur, Duff, Henry J., Jenne, Craig N., Muruve, Daniel A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Nephrology 2018
Gaiak:
Basic Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875955/
https://ncbi.nlm.nih.gov/pubmed/29439156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017080863
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