Small molecule inhibitors of anthrax edema factor

Anthrax is a highly lethal disease caused by the Gram-(+) bacteria Bacillus anthracis. Edema toxin (ET) is a major contributor to the pathogenesis of disease in humans exposed to B. anthracis. ET is a bipartite toxin composed of two proteins secreted by the vegetative bacteria, edema factor (EF) and...

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Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Jiao, Guan-Sheng, Kim, Seongjin, Moayeri, Mahtab, Thai, April, Cregar-Hernandez, Lynne, McKasson, Linda, O’Malley, Sean, Leppla, Stephen H., Johnson, Alan T.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875723/
https://ncbi.nlm.nih.gov/pubmed/29198864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.11.040
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