Abuse-related effects of subtype-selective GABA(A) receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats

RATIONALE: GABA(A) Positive Allosteric Modulators (GABA(A) PAMs), such as diazepam and zolpidem, are used clinically for anxiety and insomnia, but abuse-liability is a concern. Novel GABA(A) PAMS may have lower abuse-liability while retaining clinical utility. OBJECTIVE: The present study compared a...

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Pubblicato in:Psychopharmacology (Berl)
Autori principali: Schwienteck, Kathryn L., Li, Guanguan, Poe, Michael M., Cook, James M., Banks, Matthew L., Negus, S. Stevens
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875719/
https://ncbi.nlm.nih.gov/pubmed/28365836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-017-4615-8
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