Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression

BACKGROUND: DNA methylation plays a vital role in the cell, but loss-of-function mutations of the maintenance methyltransferase DNMT1 in normal human cells are lethal, precluding target identification, and existing hypomorphic lines are tumour cells. We generated instead a hypomorphic series in norm...

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Veröffentlicht in:Epigenetics Chromatin
Hauptverfasser: O’Neill, Karla M., Irwin, Rachelle E., Mackin, Sarah-Jayne, Thursby, Sara-Jayne, Thakur, Avinash, Bertens, Ciske, Masala, Laura, Loughery, Jayne E. P., McArt, Darragh G., Walsh, Colum P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875016/
https://ncbi.nlm.nih.gov/pubmed/29598829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-018-0182-4
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