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Prediction of Drug-Drug Interactions with Bupropion and Its Metabolites as CYP2D6 Inhibitors Using a Physiologically-Based Pharmacokinetic Model

The potential of inhibitory metabolites of perpetrator drugs to contribute to drug-drug interactions (DDIs) is uncommon and underestimated. However, the occurrence of unexpected DDI suggests the potential contribution of metabolites to the observed DDI. The aim of this study was to develop a physiol...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Xue, Caifu, Zhang, Xunjie, Cai, Weimin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874814/
https://ncbi.nlm.nih.gov/pubmed/29267251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics10010001
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