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Prediction of Drug-Drug Interactions with Bupropion and Its Metabolites as CYP2D6 Inhibitors Using a Physiologically-Based Pharmacokinetic Model

The potential of inhibitory metabolites of perpetrator drugs to contribute to drug-drug interactions (DDIs) is uncommon and underestimated. However, the occurrence of unexpected DDI suggests the potential contribution of metabolites to the observed DDI. The aim of this study was to develop a physiol...

詳細記述

保存先:
書誌詳細
出版年:Pharmaceutics
主要な著者: Xue, Caifu, Zhang, Xunjie, Cai, Weimin
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874814/
https://ncbi.nlm.nih.gov/pubmed/29267251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics10010001
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