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Improved Syntheses of the mGlu(5) Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling
The Sonogashira cross-coupling, a key step in the syntheses of the mGlu(5) antagonists MMPEP and MTEP, provided an improved three-step method for the preparation of MMPEP in 62% overall yield. Using Spartan molecular modeling kit an explanation for the failure to employ analogues method in the synth...
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| Veröffentlicht in: | Pharmaceuticals (Basel) |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5874720/ https://ncbi.nlm.nih.gov/pubmed/29461503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph11010024 |
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