Synthesis, radiolabelling and in vitro and in vivo evaluation of a novel fluorinated ABP688 derivative for the PET imaging of metabotropic glutamate receptor subtype 5

(E)-3-(Pyridin-2-ylethynyl)cyclohex-2-enone O-(2-(3-(18)F-fluoropropoxy)ethyl) oxime ([(18)F]-PSS223) was evaluated in vitro and in vivo to establish its potential as a PET tracer for imaging metabotropic glutamate receptor subtype 5 (mGluR5). [(18)F]-PSS223 was obtained in 20% decay corrected radio...

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Main Authors: Sephton, Selena Milicevic, Dennler, Patrick, Leutwiler, Dominique S, Mu, Linjing, Wanger-Baumann, Cindy A, Schibli, Roger, Krämer, Stefanie D, Ametamey, Simon M
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478118/
https://ncbi.nlm.nih.gov/pubmed/23133799
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