Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model

INTRODUCTION: Increasing use of factor Xa (FXa) inhibitors necessitates effective reversal agents to manage bleeding. Andexanet alfa, a novel modified recombinant human FXa, rapidly reverses the anticoagulation effects of direct and indirect FXa inhibitors. OBJECTIVE: To evaluate the ability of ande...

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Udgivet i:PLoS One
Main Authors: Lu, Genmin, Pine, Polly, Leeds, Janet M., DeGuzman, Francis, Pratikhya, Pratikhya, Lin, Joyce, Malinowski, John, Hollenbach, Stanley J., Curnutte, John T., Conley, Pamela B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874076/
https://ncbi.nlm.nih.gov/pubmed/29590221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195122
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