Pain control through selective chemo-axotomy of centrally projecting TRPV1(+) sensory neurons

Agonists of the vanilloid receptor transient vanilloid potential 1 (TRPV1) are emerging as highly efficacious nonopioid analgesics in preclinical studies. These drugs selectively lesion TRPV1(+) primary sensory afferents, which are responsible for the transmission of many noxious stimulus modalities...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Sapio, Matthew R., Neubert, John K., LaPaglia, Danielle M., Maric, Dragan, Keller, Jason M., Raithel, Stephen J., Rohrs, Eric L., Anderson, Ethan M., Butman, John A., Caudle, Robert M., Brown, Dorothy C., Heiss, John D., Mannes, Andrew J., Iadarola, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873867/
https://ncbi.nlm.nih.gov/pubmed/29408808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94331
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