Pain control through selective chemo-axotomy of centrally projecting TRPV1(+) sensory neurons

Agonists of the vanilloid receptor transient vanilloid potential 1 (TRPV1) are emerging as highly efficacious nonopioid analgesics in preclinical studies. These drugs selectively lesion TRPV1(+) primary sensory afferents, which are responsible for the transmission of many noxious stimulus modalities...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Sapio, Matthew R., Neubert, John K., LaPaglia, Danielle M., Maric, Dragan, Keller, Jason M., Raithel, Stephen J., Rohrs, Eric L., Anderson, Ethan M., Butman, John A., Caudle, Robert M., Brown, Dorothy C., Heiss, John D., Mannes, Andrew J., Iadarola, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873867/
https://ncbi.nlm.nih.gov/pubmed/29408808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94331
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