Pain control through selective chemo-axotomy of centrally projecting TRPV1(+) sensory neurons

Agonists of the vanilloid receptor transient vanilloid potential 1 (TRPV1) are emerging as highly efficacious nonopioid analgesics in preclinical studies. These drugs selectively lesion TRPV1(+) primary sensory afferents, which are responsible for the transmission of many noxious stimulus modalities...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Sapio, Matthew R., Neubert, John K., LaPaglia, Danielle M., Maric, Dragan, Keller, Jason M., Raithel, Stephen J., Rohrs, Eric L., Anderson, Ethan M., Butman, John A., Caudle, Robert M., Brown, Dorothy C., Heiss, John D., Mannes, Andrew J., Iadarola, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873867/
https://ncbi.nlm.nih.gov/pubmed/29408808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94331
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