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Thermal A-δ Nociceptors, Identified by Transcriptomics, Express Higher Levels of Anesthesia-Sensitive Receptors Than Thermal C-Fibers and Are More Suppressible by Low-Dose Isoflurane

We investigated the effect of isoflurane on 2 main types of thermal nociceptors: A-δ and C-fibers. Surprisingly, 1% inhaled isoflurane led to a hyperalgesic response to C-fiber thermal stimulation, whereas responses to A-δ thermal stimulation were blunted. We explored the hypothesis that differences...

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Dades bibliogràfiques
Publicat a:Anesth Analg
Autors principals: Raithel, Stephen J., Sapio, Matthew R., Iadarola, Michael J., Mannes, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121155/
https://ncbi.nlm.nih.gov/pubmed/28991117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000002505
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