Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope

Broadly neutralizing antibodies (bNAbs) isolated from HIV-1-infected individuals inform HIV-1 vaccine design efforts. Developing bNAbs with increased efficacy requires understanding how antibodies interact with the native oligomannose and complex-type N-glycan shield that hides most protein epitopes...

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Publicat a:Nat Commun
Autors principals: Barnes, Christopher O., Gristick, Harry B., Freund, Natalia T., Escolano, Amelia, Lyubimov, Artem Y., Hartweger, Harald, West, Anthony P., Cohen, Aina E., Nussenzweig, Michel C., Bjorkman, Pamela J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871869/
https://ncbi.nlm.nih.gov/pubmed/29593217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03632-y
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