Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Accumulating evidence indicates that the senescence-associated secretory phenotype (SASP) contributes to many aspects of physiology and disease. Thus, controlling the SASP will have tremendous impacts on our health. However, our understanding of SASP regulation is far from complete. Here, we show th...

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Vydáno v:Nat Commun
Hlavní autoři: Takahashi, Akiko, Loo, Tze Mun, Okada, Ryo, Kamachi, Fumitaka, Watanabe, Yoshihiro, Wakita, Masahiro, Watanabe, Sugiko, Kawamoto, Shimpei, Miyata, Kenichi, Barber, Glen N., Ohtani, Naoko, Hara, Eiji
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871854/
https://ncbi.nlm.nih.gov/pubmed/29593264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03555-8
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