ALK(G1269A) mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

Inflammatory myofibroblastic tumors are rare mesenchymal neoplasms frequently harboring oncogenic chromosomal rearrangements, most commonly, involving the ALK (anaplastic lymphoma kinase) gene. Treatment of this molecularly defined subgroup with the anaplastic lymphoma kinase inhibitor crizotinib ha...

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Vydáno v:NPJ Precis Oncol
Hlavní autoři: Michels, Sebastian Y. F., Scheel, Andreas H., Wündisch, Thomas, Heuckmann, Johannes M., Menon, Roopika, Puesken, Michael, Kobe, Carsten, Pasternack, Helen, Heydt, Carina, Scheffler, Matthias, Fischer, Rieke, Schultheis, Anne M., Merkelbach-Bruse, Sabine, Heukamp, Lukas, Büttner, Reinhard, Wolf, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
Case Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871789/
https://ncbi.nlm.nih.gov/pubmed/29872693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-017-0004-3
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