ALK(G1269A) mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

Inflammatory myofibroblastic tumors are rare mesenchymal neoplasms frequently harboring oncogenic chromosomal rearrangements, most commonly, involving the ALK (anaplastic lymphoma kinase) gene. Treatment of this molecularly defined subgroup with the anaplastic lymphoma kinase inhibitor crizotinib ha...

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Bibliografiska uppgifter
I publikationen:NPJ Precis Oncol
Huvudupphovsmän: Michels, Sebastian Y. F., Scheel, Andreas H., Wündisch, Thomas, Heuckmann, Johannes M., Menon, Roopika, Puesken, Michael, Kobe, Carsten, Pasternack, Helen, Heydt, Carina, Scheffler, Matthias, Fischer, Rieke, Schultheis, Anne M., Merkelbach-Bruse, Sabine, Heukamp, Lukas, Büttner, Reinhard, Wolf, Jürgen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
Ämnen:
Case Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871789/
https://ncbi.nlm.nih.gov/pubmed/29872693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-017-0004-3
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