ALK(G1269A) mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

Inflammatory myofibroblastic tumors are rare mesenchymal neoplasms frequently harboring oncogenic chromosomal rearrangements, most commonly, involving the ALK (anaplastic lymphoma kinase) gene. Treatment of this molecularly defined subgroup with the anaplastic lymphoma kinase inhibitor crizotinib ha...

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Foilsithe in:NPJ Precis Oncol
Main Authors: Michels, Sebastian Y. F., Scheel, Andreas H., Wündisch, Thomas, Heuckmann, Johannes M., Menon, Roopika, Puesken, Michael, Kobe, Carsten, Pasternack, Helen, Heydt, Carina, Scheffler, Matthias, Fischer, Rieke, Schultheis, Anne M., Merkelbach-Bruse, Sabine, Heukamp, Lukas, Büttner, Reinhard, Wolf, Jürgen
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
Ábhair:
Case Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871789/
https://ncbi.nlm.nih.gov/pubmed/29872693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-017-0004-3
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