ALK(G1269A) mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

Inflammatory myofibroblastic tumors are rare mesenchymal neoplasms frequently harboring oncogenic chromosomal rearrangements, most commonly, involving the ALK (anaplastic lymphoma kinase) gene. Treatment of this molecularly defined subgroup with the anaplastic lymphoma kinase inhibitor crizotinib ha...

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Detalhes bibliográficos
Publicado no:NPJ Precis Oncol
Main Authors: Michels, Sebastian Y. F., Scheel, Andreas H., Wündisch, Thomas, Heuckmann, Johannes M., Menon, Roopika, Puesken, Michael, Kobe, Carsten, Pasternack, Helen, Heydt, Carina, Scheffler, Matthias, Fischer, Rieke, Schultheis, Anne M., Merkelbach-Bruse, Sabine, Heukamp, Lukas, Büttner, Reinhard, Wolf, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871789/
https://ncbi.nlm.nih.gov/pubmed/29872693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-017-0004-3
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