Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2

Trib2 pseudokinase has oncogenic and tumour suppressive functions depending on the cellular context. We investigated the ability of Trib2 to transform different haemopoietic stem and progenitor cells (HSPCs). Our study identified the granulocyte-macrophage progenitor (GMP) subpopulation as a potent...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: O’Connor, Caitriona, Yalla, Krishna, Salomé, Mara, Moka, Hothri Ananyambica, Castañeda, Eduardo Gómez, Eyers, Patrick A., Keeshan, Karen
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871090/
https://ncbi.nlm.nih.gov/pubmed/29599919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24525
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires