Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2

Trib2 pseudokinase has oncogenic and tumour suppressive functions depending on the cellular context. We investigated the ability of Trib2 to transform different haemopoietic stem and progenitor cells (HSPCs). Our study identified the granulocyte-macrophage progenitor (GMP) subpopulation as a potent...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: O’Connor, Caitriona, Yalla, Krishna, Salomé, Mara, Moka, Hothri Ananyambica, Castañeda, Eduardo Gómez, Eyers, Patrick A., Keeshan, Karen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2018
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871090/
https://ncbi.nlm.nih.gov/pubmed/29599919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24525
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