Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2

Trib2 pseudokinase has oncogenic and tumour suppressive functions depending on the cellular context. We investigated the ability of Trib2 to transform different haemopoietic stem and progenitor cells (HSPCs). Our study identified the granulocyte-macrophage progenitor (GMP) subpopulation as a potent...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: O’Connor, Caitriona, Yalla, Krishna, Salomé, Mara, Moka, Hothri Ananyambica, Castañeda, Eduardo Gómez, Eyers, Patrick A., Keeshan, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871090/
https://ncbi.nlm.nih.gov/pubmed/29599919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24525
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