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Structure of rat BCKD kinase: Nucleotide-induced domain communication in a mitochondrial protein kinase
Mitochondrial protein kinases (mPKs) are molecular switches that down-regulate the oxidation of branched-chain α-ketoacids and pyruvate. Elevated levels of these metabolites are implicated in disease states such as insulin-resistant Type II diabetes, branched-chain ketoaciduria, and primary lactic a...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The National Academy of Sciences
2001
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC58710/ https://ncbi.nlm.nih.gov/pubmed/11562470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.201220098 |
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