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Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle
Cdc6p and the origin recognition complex (ORC) are essential for assembly of a pre-replicative complex (preRC) at origins of replication, before the initiation of DNA synthesis. In the absence of Cdc6p, cells fail to initiate DNA replication and undergo a “reductional” mitosis, in which the unreplic...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC58709/ https://ncbi.nlm.nih.gov/pubmed/11572976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.201387198 |
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