Implication of 4E-BP1 protein dephosphorylation and accumulation in pancreatic cancer cell death induced by combined gemcitabine and TRAIL

Pancreatic cancer cells show varying sensitivity to the anticancer effects of gemcitabine. However, as a chemotherapeutic agent, gemcitabine can cause intolerably high levels of toxicity and patients often develop resistance to the beneficial effects of this drug. Combination studies show that use o...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Elia, Androulla, Henry-Grant, Ricky, Adiseshiah, Charlotte, Marboeuf, Catherine, Buckley, Rebecca J, Clemens, Michael J, Mudan, Satvinder, Pyronnet, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870593/
https://ncbi.nlm.nih.gov/pubmed/29233971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0001-z
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