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Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders
Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the potential to knockdown previously thought ‘undruggable’ targets at sub-stoichiometric concentrations in ways not possible using conventional inhibito...
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| Udgivet i: | Essays Biochem |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5869862/ https://ncbi.nlm.nih.gov/pubmed/29118097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/EBC20170041 |
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