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Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders

Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the potential to knockdown previously thought ‘undruggable’ targets at sub-stoichiometric concentrations in ways not possible using conventional inhibito...

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Publicat a:Essays Biochem
Autors principals: Hughes, Scott J., Ciulli, Alessio
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869862/
https://ncbi.nlm.nih.gov/pubmed/29118097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/EBC20170041
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