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Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology

Targeting epigenetic proteins is a rapidly growing area for medicinal chemistry and drug discovery. Recent years have seen an explosion of interest in developing small molecules binding to bromodomains, the readers of acetyl-lysine modifications. A plethora of co-crystal structures has motivated foc...

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Detalhes bibliográficos
Publicado no:Future Med Chem
Main Authors: Galdeano, Carles, Ciulli, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321501/
https://ncbi.nlm.nih.gov/pubmed/27193077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2016-0059
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