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Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology
Targeting epigenetic proteins is a rapidly growing area for medicinal chemistry and drug discovery. Recent years have seen an explosion of interest in developing small molecules binding to bromodomains, the readers of acetyl-lysine modifications. A plethora of co-crystal structures has motivated foc...
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| Vydáno v: | Future Med Chem |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5321501/ https://ncbi.nlm.nih.gov/pubmed/27193077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2016-0059 |
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