Simian Immunodeficiency Virus (SIV)-Specific Chimeric Antigen Receptor-T Cells Engineered to Target B Cell Follicles and Suppress SIV Replication

There is a need to develop improved methods to treat and potentially cure HIV infection. During chronic HIV infection, replication is concentrated within T follicular helper cells (Tfh) located within B cell follicles, where low levels of virus-specific CTL permit ongoing viral replication. We previ...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Haran, Kumudhini Preethi, Hajduczki, Agnes, Pampusch, Mary S., Mwakalundwa, Gwantwa, Vargas-Inchaustegui, Diego A., Rakasz, Eva G., Connick, Elizabeth, Berger, Edward A., Skinner, Pamela J.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869724/
https://ncbi.nlm.nih.gov/pubmed/29616024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00492
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