The human IL-15 superagonist ALT-803 directs SIV-specific CD8(+) T cells into B-cell follicles

Sequestering of latent HIV in follicular helper T cells within B-cell follicles that largely exclude cytotoxic T cells is a major barrier to cellular immune-based approaches to eradicate HIV. Here, we show that the clinical-grade human interleukin-15 (IL-15) superagonist ALT-803 activates and redire...

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Bibliografski detalji
Izdano u:Blood Adv
Glavni autori: Webb, Gabriela M., Li, Shengbin, Mwakalundwa, Gwantwa, Folkvord, Joy M., Greene, Justin M., Reed, Jason S., Stanton, Jeffery J., Legasse, Alfred W., Hobbs, Theodore, Martin, Lauren D., Park, Byung S., Whitney, James B., Jeng, Emily K., Wong, Hing C., Nixon, Douglas F., Jones, R. Brad, Connick, Elizabeth, Skinner, Pamela J., Sacha, Jonah B.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2018
Teme:
Immunobiology and Immunotherapy
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787870/
https://ncbi.nlm.nih.gov/pubmed/29365313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017012971
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