A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes

Human botulism is most commonly caused by botulinum neurotoxin (BoNT) serotypes A, B, and E. For this work, we sought to develop a human monoclonal antibody (mAb)-based antitoxin capable of binding and neutralizing multiple subtypes of BoNT/E. Libraries of yeast-displayed single chain Fv (scFv) anti...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Garcia-Rodriguez, Consuelo, Razai, Ali, Geren, Isin N., Lou, Jianlong, Conrad, Fraser, Wen, Wei-Hua, Farr-Jones, Shauna, Smith, Theresa J., Brown, Jennifer L., Skerry, Janet C., Smith, Leonard A., Marks, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869393/
https://ncbi.nlm.nih.gov/pubmed/29494481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins10030105
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