N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis

The conjugation of amino acids to the protein N termini is universally observed in eukaryotes and prokaryotes, yet its functions remain poorly understood. In eukaryotes, the amino acid l-arginine (l-Arg) is conjugated to N-terminal Asp (Nt-Asp), Glu, Gln, Asn, and Cys, directly or associated with po...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Yoo, Young Dong, Mun, Su Ran, Ji, Chang Hoon, Sung, Ki Woon, Kang, Keum Young, Heo, Ah Jung, Lee, Su Hyun, An, Jee Young, Hwang, Joonsung, Xie, Xiang-Qun, Ciechanover, Aaron, Kim, Bo Yeon, Kwon, Yong Tae
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866579/
https://ncbi.nlm.nih.gov/pubmed/29507222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719110115
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