The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins

The N-terminal amino acid of a protein is an essential determinant of ubiquitination and subsequent proteasomal degradation in the N-end rule pathway. Using para-chloroamphetamine (PCA), a specific inhibitor of the arginylation branch of the pathway (Arg/N-end rule pathway), we identified that block...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Jiang, Yanxialei, Lee, Jeeyoung, Lee, Jung Hoon, Lee, Joon Won, Kim, Ji Hyeon, Choi, Won Hoon, Yoo, Young Dong, Cha-Molstad, Hyunjoo, Kim, Bo Yeon, Kwon, Yong Tae, Noh, Sue Ah, Kim, Kwang Pyo, Lee, Min Jae
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103369/
https://ncbi.nlm.nih.gov/pubmed/27560450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1222991
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