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Nutrient-driven O-GlcNAc cycling influences autophagic flux and neurodegenerative proteotoxicity
O-GlcNAcylation is an abundant post-translational modification implicated in human neurodegenerative diseases. We showed that loss-of-function of OGT (O-linked GlcNAc transferase) alleviated, while loss of OGA (O-GlcNAc selective β-N-acetyl-D-glucosaminidase) enhanced, the proteotoxicity of C. elega...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3627674/ https://ncbi.nlm.nih.gov/pubmed/23328586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.23459 |
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