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Attenuation of accelerated renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade
The intrarenal renin angiotensin system (RAS) is activated in polycystic kidney disease. We have recently shown in the Pkd1 mouse that Gen 2 antisense oligonucleotide (ASO), which suppresses angiotensinogen (Agt) synthesis, is efficacious in slowing kidney cyst formation compared with lisinopril. Th...
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| Veröffentlicht in: | Am J Physiol Renal Physiol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5866454/ https://ncbi.nlm.nih.gov/pubmed/29021226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00389.2017 |
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