Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model

Activation of the intrarenal renin angiotensin system (RAS) is believed to play an important role in the development of hypertension and cystogenesis in autosomal dominant polycystic kidney disease (ADPKD). Results of clinical studies testing RAS inhibitors in slowing the progression of cystic disea...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Saigusa, Takamitsu, Dang, Yujing, Mullick, Adam E., Yeh, Steve T., Zile, Michael R., Baicu, Catalin F., Bell, P. Darwin
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684522/
https://ncbi.nlm.nih.gov/pubmed/26391272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-279299
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