POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that leptin’s actions are mediated through pro-opiomelanocortin (POMC) neurons that express leptin receptors (LEPRs). However, previous studies have...

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Vydáno v:eLife
Hlavní autoři: Caron, Alexandre, Dungan Lemko, Heather M, Castorena, Carlos M, Fujikawa, Teppei, Lee, Syann, Lord, Caleb C, Ahmed, Newaz, Lee, Charlotte E, Holland, William L, Liu, Chen, Elmquist, Joel K
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Human Biology and Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866097/
https://ncbi.nlm.nih.gov/pubmed/29528284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33710
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