The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C

Atypical antipsychotics such as olanzapine often induce excessive weight gain and type 2 diabetes. However, the mechanisms underlying these drug-induced metabolic perturbations remain poorly understood. Here, we used an experimental model that reproduces olanzapine-induced hyperphagia and obesity in...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Lord, Caleb C., Wyler, Steven C., Wan, Rong, Castorena, Carlos M., Ahmed, Newaz, Mathew, Dias, Lee, Syann, Liu, Chen, Elmquist, Joel K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669575/
https://ncbi.nlm.nih.gov/pubmed/28805659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93362
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