The Antipsychotic Olanzapine Interacts with the Gut Microbiome to Cause Weight Gain in Mouse

The second-generation antipsychotic olanzapine is effective in reducing psychotic symptoms but can cause extreme weight gain in human patients. We investigated the role of the gut microbiota in this adverse drug effect using a mouse model. First, we used germ-free C57BL/6J mice to demonstrate that g...

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Udgivet i:PLoS One
Main Authors: Morgan, Andrew P., Crowley, James J., Nonneman, Randal J., Quackenbush, Corey R., Miller, Cheryl N., Ryan, Allison K., Bogue, Molly A., Paredes, Sur Herrera, Yourstone, Scott, Carroll, Ian M., Kawula, Thomas H., Bower, Maureen A., Sartor, R. Balfour, Sullivan, Patrick F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266663/
https://ncbi.nlm.nih.gov/pubmed/25506936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115225
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