The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain

Atypical antipsychotics such as risperidone cause drug-induced metabolic syndrome. However, the underlying mechanisms remain largely unknown. Here, we report a new mouse model that reliably reproduces risperidone-induced weight gain, adiposity, and glucose intolerance. We found that risperidone trea...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Li, Li, Yoo, Eun-Seon, Li, Xiujuan, Wyler, Steven C., Chen, Xiameng, Wan, Rong, Arnold, Amanda G., Birnbaum, Shari G., Jia, Lin, Sohn, Jong-Woo, Liu, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126977/
https://ncbi.nlm.nih.gov/pubmed/33978701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202484
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