Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

Leptin action on its receptor (LEPR) stimulates energy expenditure and reduces food intake, thereby lowering body weight. One leptin-sensitive target cell mediating these effects on energy balance is the proopiomelano­cortin (POMC) neuron. Recent evidence suggests that the action of leptin on POMC n...

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Hauptverfasser: Berglund, Eric D., Vianna, Claudia R., Donato, Jose, Kim, Mi Hwa, Chuang, Jen-Chieh, Lee, Charlotte E., Lauzon, Danielle A., Lin, Peagan, Brule, Laura J., Scott, Michael M., Coppari, Roberto, Elmquist, Joel K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287225/
https://ncbi.nlm.nih.gov/pubmed/22326958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59816
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