Direct Insulin and Leptin Action in Pro-opiomelanocortin Neurons is Required for Normal Glucose Homeostasis and Fertility

Circulating leptin and insulin convey information regarding energy stores to the central nervous system, particularly the hypothalamus. Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy balance and glucose homeostasis and express leptin and insulin receptors. However, the physiologica...

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Hauptverfasser: Hill, Jennifer W., Elias, Carol F., Fukuda, Makoto, Williams, Kevin W., Berglund, Eric D., Holland, William L., Cho, You-Ree, Chuang, Jen-Chieh, Xu, Yong, Choi, Michelle, Lauzon, Danielle, Lee, Charlotte E., Coppari, Roberto, Richardson, James A., Zigman, Jeffrey M., Chua, Streamson, Scherer, Philipp E., Lowell, Bradford B., Brüning, Jens C., Elmquist, Joel K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854520/
https://ncbi.nlm.nih.gov/pubmed/20374961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.03.002
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