5-HT(2C)Rs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver

Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed insulin resistance in the liver, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT(2C)R deficiency also abolished anti-diabetic effects of mCPP (a 5-HT(2C)R agonist) while such effects were re...

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Detalhes bibliográficos
Main Authors: Xu, Yong, Berglund, Eric D., Sohn, Jong-Woo, Holland, William L., Chuang, Jen-Chieh, Fukuda, Makoto, Rossi, Jari, Williams, Kevin W., Jones, Juli E., Zigman, Jeffrey M., Lowell, Bradford B., Scherer, Philipp E., Elmquist, Joel K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059249/
https://ncbi.nlm.nih.gov/pubmed/21037584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2664
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