POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that leptin’s actions are mediated through pro-opiomelanocortin (POMC) neurons that express leptin receptors (LEPRs). However, previous studies have...

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Gepubliceerd in:eLife
Hoofdauteurs: Caron, Alexandre, Dungan Lemko, Heather M, Castorena, Carlos M, Fujikawa, Teppei, Lee, Syann, Lord, Caleb C, Ahmed, Newaz, Lee, Charlotte E, Holland, William L, Liu, Chen, Elmquist, Joel K
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2018
Onderwerpen:
Human Biology and Medicine
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866097/
https://ncbi.nlm.nih.gov/pubmed/29528284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33710
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