Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

Intrachromosomal amplification of chromosome 21 is a heterogeneous chromosomal rearrangement occurring in 2% of cases of childhood precursor B-cell acute lymphoblastic leukemia. These abnormalities are too complex to engineer faithfully in animal models and are unrepresented in leukemia cell lines....

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Bibliografische gegevens
Gepubliceerd in:Haematologica
Hoofdauteurs: Sinclair, Paul. B., Blair, Helen H., Ryan, Sarra L., Buechler, Lars, Cheng, Joanna, Clayton, Jake, Hanna, Rebecca, Hollern, Shaun, Hawking, Zoe, Bashton, Matthew, Schwab, Claire J., Jones, Lisa, Russell, Lisa J., Marr, Helen, Carey, Peter, Halsey, Christina, Heidenreich, Olaf, Moorman, Anthony V., Harrison, Christine J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ferrata Storti Foundation 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865429/
https://ncbi.nlm.nih.gov/pubmed/29449437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.172304
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