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The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

BACKGROUND: C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis....

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Bibliografiske detaljer
Udgivet i:BMC Cancer
Main Authors: Matsushita, Junya, Okamura, Kazuyuki, Nakabayashi, Kazuhiko, Suzuki, Takehiro, Horibe, Yu, Kawai, Tomoko, Sakurai, Toshihiro, Yamashita, Satoshi, Higami, Yoshikazu, Ichihara, Gaku, Hata, Kenichiro, Nohara, Keiko
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865360/
https://ncbi.nlm.nih.gov/pubmed/29566670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4221-0
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