The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

BACKGROUND: C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis....

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Matsushita, Junya, Okamura, Kazuyuki, Nakabayashi, Kazuhiko, Suzuki, Takehiro, Horibe, Yu, Kawai, Tomoko, Sakurai, Toshihiro, Yamashita, Satoshi, Higami, Yoshikazu, Ichihara, Gaku, Hata, Kenichiro, Nohara, Keiko
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865360/
https://ncbi.nlm.nih.gov/pubmed/29566670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4221-0
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