The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

BACKGROUND: C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis....

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Matsushita, Junya, Okamura, Kazuyuki, Nakabayashi, Kazuhiko, Suzuki, Takehiro, Horibe, Yu, Kawai, Tomoko, Sakurai, Toshihiro, Yamashita, Satoshi, Higami, Yoshikazu, Ichihara, Gaku, Hata, Kenichiro, Nohara, Keiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865360/
https://ncbi.nlm.nih.gov/pubmed/29566670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4221-0
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