Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis

Heme is required for cell respiration and survival. Nevertheless, its intracellular levels need to be finely regulated to avoid heme excess, which may catalyze the production of reactive oxygen species (ROS) and promote cell death. Here, we show that alteration of heme homeostasis in endothelial cel...

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Bibliografske podrobnosti
izdano v:Cell Death Differ
Main Authors: Petrillo, Sara, Chiabrando, Deborah, Genova, Tullio, Fiorito, Veronica, Ingoglia, Giada, Vinchi, Francesca, Mussano, Federico, Carossa, Stefano, Silengo, Lorenzo, Altruda, Fiorella, Merlo, Giorgio Roberto, Munaron, Luca, Tolosano, Emanuela
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864215/
https://ncbi.nlm.nih.gov/pubmed/29229999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0001-7
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