Sumoylation of Notch1 represses its target gene expression during cell stress

The Notch signaling pathway is a key regulator of stem cells during development, and its deregulated activity is linked to developmental defects and cancer. Transcriptional activation of Notch target genes requires cleavage of the Notch receptor in response to ligand binding, production of the Notch...

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Dettagli Bibliografici
Pubblicato in:Cell Death Differ
Autori principali: Antila, Christian J. M., Rraklli, Vilma, Blomster, Henri A., Dahlström, Käthe M., Salminen, Tiina A., Holmberg, Johan, Sistonen, Lea, Sahlgren, Cecilia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864205/
https://ncbi.nlm.nih.gov/pubmed/29305585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0002-6
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