PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion

Dysregulation of the developmentally important Notch signaling pathway is implicated in several types of cancer, including breast cancer. However, the specific roles and regulation of the four different Notch receptors have remained elusive. We have previously reported that the oncogenic PIM kinases...

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Publicado en:J Biol Chem
Autores principales: Landor, Sebastian K.J., Santio, Niina M., Eccleshall, William B., Paramonov, Valeriy M., Gagliani, Ellen K., Hall, Daniel, Jin, Shao-Bo, Dahlström, Käthe M., Salminen, Tiina A., Rivero-Müller, Adolfo, Lendahl, Urban, Kovall, Rhett A., Koskinen, Päivi J., Sahlgren, Cecilia
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100066/
https://ncbi.nlm.nih.gov/pubmed/33775697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100593
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